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近来报导,在Ⅱ型高脂蛋白血症应用甲腈咪呱可以增加高密度脂蛋白胆固醇(HDL-ch)的浓度。在10名健康受试者中发现,用甲腈咪呱每日1克治疗,4周后其HDL-ch浓度显著增高。本文作者分别对甲腈咪呱每日1克和呋喃硝胺每日30~0毫克治疗时HDL、HDL_2、HDL_3胆固醇的变化进行了观察。
It has recently been reported that the application of nitrileopeptine in type II hyperlipoproteinemia increases the concentration of high-density lipoprotein cholesterol (HDL-ch). In 10 healthy subjects, it was found that 1 g daily treatment with cimetidine resulted in a significant increase in HDL-ch concentration after 4 weeks. The authors observed the changes of HDL, HDL_2 and HDL_3 cholesterol in the treatment of 1 g nitrilequam daily and 30 to 0 mg nitrofurantoin daily.