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由于发现大鼠腔内植入人造玻璃纤维(MMVF)诱发了癌症,因此关于MMVF对健康的影响产生了争论。不溶性矿物纤维植入或注入胸腔或腹腔的实验得出一个明确的结论:不管纤维的成分如何,若其大小在一定范围内,即直径<1.5μm,长度>8μm,就具有致癌性。虽然癌症的发生仅局限于啮齿类,有些专家却将实验结果外推到人,因而引起高度的警惕。但也有人对于把大鼠腔内癌症结果外推到人提出有说服力的异议。(一)流行病学调查最近对生产MMVF工厂的工人健康所作
The controversy over the health effects of MMVF arose from the discovery that intracavitary implantation of artificial glass fibers (MMVF) in rats induced cancer. Experiments with insoluble mineral fibers implanted or infused into the thorax or abdomen lead to a clear conclusion: regardless of the composition of the fiber, it is carcinogenic if its size is within a certain range, ie <1.5 μm in diameter and> 8 μm in length. Although the incidence of cancer is confined to rodents, some experts extrapolate the results of the experiment to humans, giving rise to a high degree of vigilance. But others are convincing objections to the extrapolation of intracavitary cancer outcomes in humans. (A) Epidemiological investigations have recently been conducted on the health of workers who produce MMVF plants