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目前高血压患病率明显增加,其发病机制复杂,涉及多种因素的作用。近年来的研究提示炎症与免疫因素在高血压的发病过程中起着重要作用。本文通过检测不同危险分级原发性高血压(EH)患者血清可溶性细胞间黏附分子-1(sICAM-1)水平的变化,探讨其在高血压发病中的作用。1资料与方法1.1对象根椐1999年WHO高血压诊断标准,于我院心内门诊选择EH病人80例,其中男38例,女42例。根椐病史、查体及辅助检查,按照WHO的高血压危险分级、分层标准,将高血压病人分为低危、中危、高危、极高危4组,各20例。4组间性别、年龄比较差异无显著性(均P>0.05),停药5个半衰期。同时选择与EH组相匹配的16例健康体检者为
The current prevalence of hypertension increased significantly, its pathogenesis is complex and involves a variety of factors. Recent studies suggest that inflammation and immune factors play an important role in the pathogenesis of hypertension. This article examines the changes of serum soluble intercellular adhesion molecule-1 (sICAM-1) levels in patients with different risk grades of essential hypertension (EH), and explores its role in the pathogenesis of hypertension. 1 Materials and Methods 1.1 Object 椐 椐 WHO diagnostic criteria for hypertension in 1999, 80 cases of EH patients in our hospital cardiac clinic, including 38 males and 42 females. According to WHO’s history of hypertension, physical examination and laboratory examinations, hypertension patients were divided into 4 groups according to WHO risk classification and stratification criteria, and each group consisted of 20 patients with low risk, moderate risk, high risk and very high risk. There was no significant difference in gender and age between the 4 groups (all P> 0.05), and 5 half-lives were stopped. At the same time select the EH group to match the 16 cases of health examination