消化性溃疡(以下简称溃疡病)系一种常见病。近年对溃疡病发病机理及药物治疗的研究进展较快,笔者从临床应用角度作一扼要叙述。消化性溃疡的发病机理本病发病机理迄今未完全阐明。50年代中期Hollander就以胃何以不被消化为题,概括了决定溃疡产生的两个方面,一是胃酸、胃酶的损伤,一是胃肠道自身的保护作用。一、损害因素 (一)胃酸、胃蛋白酶纯酸性胃液不仅可以破坏和消化包括胃在内的一切活组织,并可激活胃蛋白酶使之发挥消化蛋 Peptic ulcer (hereinafter referred to as ulcer disease) is a common disease. In recent years, the pathogenesis of ulcer disease and drug treatment of rapid progress, the author from a clinical application point of view to make a brief statement. The pathogenesis of peptic ulcer The pathogenesis of this disease has not been fully elucidated so far. Hollander in the mid-50s on why the stomach is not digested as the title, summarizes the decision to produce two aspects of ulcers, one gastric acid, gastric enzyme damage, one of the protective effect of the gastrointestinal tract itself. First, the damage factors (A) of gastric acid, pepsin Pure acid gastric juice can not only destroy and digest all living tissues, including the stomach, and can activate pepsin to play a digestive egg