抗生素后效应(PAE)是反映药效学的一个参数,表明了当活性抗菌药物从生长媒介中消除后一个抑制细菌生长的过程。PAE的持久性受细菌种类、抗菌药物的性质和浓度影响,同时也受一些环境因素的影响,如温度、pH、PO2,生长媒介,体液种类等。PAE的临床意义在于指导临床实践中抗菌药 The post-antibiotic effect (PAE) is a parameter that reflects pharmacodynamics, indicating a process that inhibits bacterial growth when active antibacterials are eliminated from the growth media. The persistence of PAE is influenced by the type of bacteria, the nature and concentration of the antimicrobial agent, and also by some environmental factors such as temperature, pH, PO2, growth media, and body fluids. The clinical significance of PAE is to guide the clinical practice of antimicrobial agents