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目的研究凋亡抑制基因Survivin在鼻咽癌中的表达以及Survivin的表达与鼻咽癌淋巴转移、临床分期之间的相关性。方法应用免疫组化技术分析68例鼻咽癌组织和45例鼻咽慢性炎症组织中Survivin的表达。结果68例鼻咽癌组织中,Survivin表达阳性率为69·1%(47/68),45例鼻咽慢性炎症组织中,Survivin表达阳性率为15·6%(7/45),两者比较差异有统计学意义(P<0·01)。有淋巴转移的鼻咽癌组织,Survivin表达为71·7%(33/46),无淋巴转移的鼻咽癌组织Survivin表达为63·6%(14/22),两者比较差异无统计学意义(P>0·05)。早期(临床Ⅰ、Ⅱ期)鼻咽癌组织,Survivin表达为70·6%(12/17),晚期(临床Ⅲ、Ⅳ期)鼻咽癌组织,Survivin表达为68·6%(35/51),两者比较差异无统计学意义(P>0·05)。结论Survivin的表达改变发生在鼻咽癌的早期,它的表达水平升高可能在鼻咽组织癌变早期起重要作用;Survivin的表达与鼻咽癌的转移、临床分期可能无相关。
Objective To study the expression of survivin gene in nasopharyngeal carcinoma and its relationship with lymph node metastasis and clinical stage of nasopharyngeal carcinoma. Methods Immunohistochemistry was used to analyze the expression of Survivin in 68 cases of nasopharyngeal carcinoma and 45 cases of chronic nasopharyngeal inflammation. Results The positive rate of Survivin expression was 69.1% (47/68) in 68 NPC tissues and 15.6% (7/45) in 45 nasopharyngeal chronic inflammation tissues, both The difference was statistically significant (P <0.01). Survivin expression was 71.7% (33/46) in lymphatic metastatic nasopharyngeal carcinoma tissues, and 63.6% (14/22) in nasopharyngeal carcinoma tissues without lymph node metastasis. There was no significant difference between the two groups Significance (P> 0.05). Survivin expression was 70.6% (12/17) in nasopharyngeal carcinoma (stage Ⅰ, Ⅱ) and 68.6% (35/51) in advanced stage (Ⅲ, Ⅳ) ), There was no significant difference between the two (P> 0.05). Conclusion The expression of Survivin changes in the early stage of nasopharyngeal carcinoma. The increased expression of Survivin may play an important role in the early stage of carcinogenesis of nasopharyngeal carcinoma. Survivin expression may not be related to the metastasis and clinical stage of NPC.