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阿奇霉素~([1])是一种新型的大环内酯类抗生素,广泛用于临床,适用于敏感菌所致的呼吸道、皮肤软组织感染和衣原体所致的性传播性疾病。具有抗菌谱广、不良反应小、临床应用广泛等优点~([2-3])。目前,国内已有多家药厂生产该产品及其制剂,因此制剂中有关物质的含量测定和质量控制具有必要性。试验采用HPLC-ESI-MSn联用~([4-8])的方法检测了一批乳糖酸阿奇霉素中的有关物质,并使用USP
Azithromycin ~ ([1]) is a new macrolide antibiotic that is widely used clinically in the respiratory tract, skin and soft tissue infections caused by sensitive bacteria and sexually transmitted diseases caused by chlamydia. With broad antibacterial spectrum, small adverse reactions, the advantages of a wide range of clinical applications ([2-3]). At present, there are many domestic pharmaceutical companies to produce the product and its preparation, so the determination of related substances in the preparation and quality control is necessary. A series of related substances in azithromycin lactobionate were detected by using HPLC-ESI-MSn combined with ~ ([4-8]) method, and USP