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目的 研究软组织骨化性纤维粘液样瘤 (OFT)的病理形态学特点和免疫组织化学表型 ,并探讨其组织发生。方法 采用光镜观察 (HE)和免疫组织化学标记 (LSAB法 )结合临床资料对 8例软组织骨化性纤维粘液样瘤进行临床病理学分析。结果 8例患者均为中老年人 ,年龄 43～ 78岁 ,平均 6 3岁。临床上多表现为四肢近端皮下缓慢性生长的肿块。组织学上 ,该肿瘤归纳起来有以下 3个特征性的形态 ,比较独特 ,具有诊断性意义 :(1)肿瘤境界清楚 ,有一层厚的纤维性假包膜围绕 ,多数病例于包膜内可见一层薄的不连续性骨壳 ,由成熟的化生性板层骨组成 ;(2 )肿瘤的实质由多个大小不一、细胞密度不均的小叶组成 ,小叶内的瘤细胞呈圆形、卵圆形或短梭形 ,胞质淡染或呈嗜伊红色 ,核染色质细致 ,核分裂象偶见 ;(3)瘤细胞呈特征性的巢状、条束状或纤细的网格状排列 ,肿瘤的基质呈特征性的纤维粘液样。 7例行免疫组织化学标记 ,结果显示瘤细胞强阳性表达波形蛋白和神经元特异性烯醇化酶 (7/ 7) ,多数表达S 10 0蛋白 (6 / 7) ,部分表达结蛋白 (2 / 7)。 7例均有随访资料 ,2例分别于术后 2年及 15年复发。结论 软组织骨化性纤维粘液样瘤是一种好发于中老年人的具潜在低度恶性的软组织肿瘤 ,其特征性的骨壳结构、独特的细胞形态及?
Objective To study the pathological and immunohistochemical phenotypes of soft tissue ossifying fibromyembroid tumors (OFT) and explore their histogenesis. Methods The clinical pathological analysis of 8 cases of soft tissue ossification fibromyxoid tumors were performed by light microscopy (HE) and immunohistochemistry (LSAB) combined with clinical data. Results All 8 patients were middle-aged and elderly patients, aged 43 to 78 years old, with an average of 6 3 years old. Clinically, there are many clinical manifestations of slow-growing subcutaneous proximal limbs. Histologically, the tumors are characterized by the following three distinctive features, which are unique and have diagnostic significance: (1) The tumor boundary is clear and there is a thick layer of fibroid pseudocapsules. Most cases are visible in the capsule. A thin layer of discontinuity is composed of mature metaplastic lamellar bone; (2) the nature of the tumor is composed of a plurality of leaflets of various sizes and uneven cell densities, and the tumor cells in the lobules are round, Oval or short spindle, lightly cytoplasm or eosinophilic, nuclear chromatin fine, mitotic figures are sporadic; (3) neoplastic cells with characteristic nests, bands, or slender grids The tumor’s stroma is characterized by a characteristic fibrous mucous membrane. 7 routine immunohistochemical markers showed that the tumor cells strongly positively expressed vimentin and neuron specific enolase (7/7), most expressed S 10 0 protein (6/7), partially expressed desmin (2 / 7). All 7 cases had follow-up data, 2 cases recurred at 2 and 15 years after surgery. Conclusion Soft tissue ossification fibromyxoma-like tumor is a kind of potentially low-grade soft tissue tumor that occurs in the middle-aged and elderly people. Its characteristic bone structure, unique cell morphology and?