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目的:探讨子宫内膜间质肿瘤(EST)中CD10、PR、Ki-67的表达水平与临床生物学特性的关系。方法:对9例子宫内膜间质结节(ESN)、24例子宫内膜间质肉瘤(ESS)和12例未分化子宫内膜肉瘤(UES)用免疫组化法检测CD10,PR,Ki-67的表达情况,并与临床表现及随访结果对照。结果:CD10,PR在ESN,ESS,UES中表达逐渐减弱,而Ki-67则逐渐增强,在ESS中阳性率分别为95.8%、38.0%,Ki-67指数为38%,与UES差异有统计学意义(P<0.05),而ESN与ESS间差异无统计学意义(P>0.05)。结论:EST生物学行为和预后可能与CD10、PR、Ki-67阳性表达的数量和强度有关;PR常规检测可作为判断预后的指标及指导孕激素辅助治疗。
Objective: To investigate the relationship between the expression of CD10, PR and Ki-67 in endometrial stromal tumors (ESTs) and clinical biological characteristics. Methods: Nine cases of endometrial stromal nodules (ESN), 24 cases of endometrial stromal sarcoma (ESS) and 12 cases of undifferentiated endometrial sarcoma (UES) were detected by immunohistochemistry CD10, PR, Ki -67 expression, and with the clinical manifestations and follow-up results of the control. Results: The expressions of CD10 and PR in ESN, ESS and UES gradually decreased, while Ki-67 gradually increased. The positive rates of ESR and ESR were 95.8% and 38.0%, respectively. The Ki-67 index was 38% (P <0.05), while there was no significant difference between ESN and ESS (P> 0.05). Conclusion: The biological behavior and prognosis of EST may be related to the quantity and intensity of positive expression of CD10, PR and Ki-67. The routine test of PR can be used as an index to predict the prognosis and guide the adjuvant treatment of progestin.