Stork和Ringold,报告了孕甾烯类化合物在四氢呋喃中用碘和氧化钙处理,可直接导入G_(21)-碘。此碘化物在无水丙酮中与醋酸钾反应,即成G_(21)-醋酸酯,两步反应的产率为60％。黄鸣龙等将此反应应用于可的松醋酸,酯的合成中,并在方法上稍加改进,两步反应的产率为59％。此后陆续见有将此法应用于甾体化合物的合成中,但产率往往欠佳。 Stork and Ringold report that pregnenoids are treated with iodine and calcium oxide in tetrahydrofuran and can be directly introduced into G_ (21) -iodine. The iodide reacted with potassium acetate in anhydrous acetone to give G_ (21) -acetate. The yield of the two-step reaction was 60%. Huang Minglong such reaction will be used in the synthesis of cortisone acetate, ester and slightly improved in the method, the yield of two-step reaction was 59%. Since then this method has been applied to the synthesis of steroidal compounds, but the yield is often poor.