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本文指出,对氨基水杨酸钠(PAS)与利福平同时口服时,可使利福平的血浓度降低。共观察了69例肝肾功能正常的结核病患者,其中55例均隔天一次口服利福平、PAS、异烟肼、利福平+PAS或利福平+异烟肼,另外14例仅服利福平、异烟肼或利福平+异烟肼。有2例患者在口服利福平2～6小时后静脉滴注PAS,历时2小时。另有3例患者在晚餐后一次口服PAS,次晨又口服利福平。各受试者均于服药前及服药后2、4、6、8
This article points out that the simultaneous administration of sodium aminosalicylate (PAS) and rifampicin reduces the blood levels of rifampicin. A total of 69 patients with normal liver and kidney function were observed. Among them, 55 cases were given oral rifampicin, PAS, isoniazid, rifampicin + PAS or rifampicin + isoniazid once every other day, while the other 14 cases were served only Rifampin, isoniazid or rifampicin + isoniazid. Two patients received intravenous infusion of PAS 2 to 6 hours after oral rifampin, which lasted 2 hours. Another 3 patients were orally administered PAS orally after dinner and were again given rifampicin the next morning. All subjects were before taking and after taking 2,4,6,8