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目的核医学中传统的MIRD剂量估算方法是假设放射性药物在器官内均匀分布,用器官的平均剂量描述每个细胞及细胞核的剂量。基于核素的微观分布数据,建立微剂量的剂量估算模式,从而为核医学中诊疗计划的制定、放射药物效果和危害的预测及评价、分子核医学研究提供基础的微剂量估算及其分布研究的方法和基础数据。方法采用了放射自显影术和冰冻切片技术,建立自显影银颗粒密度与放射性药物强度的刻度曲线,确定放射性药物99mTcDTPA的微观分布。结果银颗粒密度与施入比活度的相关系数为0.9915,刻度系数为6.48×10-5Bq。细胞浆与细胞核的分布比为1.78。结论放射性药物在细胞水平的分布是不均匀的,因此在计算细胞水平的剂量时应考虑到其分布的不均匀性。
The purpose of traditional MIRD dose estimation in nuclear medicine is to assume that radiopharmaceuticals are evenly distributed within the organ and that the average dose of the organ be used to describe the dose of each cell and nucleus. Based on the microscopic distribution data of nuclides, a dose estimation mode of micro-dose is established, which can provide basic micro-dose estimates and their distribution for the development of medical plans in nuclear medicine, prediction and evaluation of radiopharmaceutical effects and hazards, molecular nuclear medicine research Method and basic data. Methods The autoradiography and frozen section technique were used to establish the calibration curves of self-developed silver particle density and radiopharmaceutical intensity to determine the microscopic distribution of radiopharmaceutical 99mTcDTPA. Results The correlation coefficient of silver particle density and applied specific activity was 0.9915 and the calibration coefficient was 6.48 × 10-5Bq. The distribution ratio of cytoplasm to nucleus was 1.78. Conclusion Radiopharmaceuticals are unevenly distributed at the cellular level, and therefore their distributional inhomogeneities should be taken into account when calculating cell-level doses.