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目的观察中药抗霉方联合氟康唑治疗呼吸道真菌感染的临床疗效。方法收集呼吸道真菌感染住院患者共43例,随机分为治疗组(23例)和对照组(20例)。治疗组予中药抗霉方、氟康唑口服,对照组予氟康唑口服。10d为1个疗程,两组治疗1-2个疗程。比较治疗前后中医证候积分,并观察真菌培养结果,计算真菌清除率。结果治疗组真菌清除率为60.87%,对照组为40.00%,两组比较差异具有统计学意义(P<0.05)。两组中医证候疗效比较,治疗组总有效率为95.65%,对照组为70.00%,差异有统计学意义(P<0.05)。结论抗霉方联合氟康唑治疗呼吸道真菌感染具有良好临床疗效。
Objective To observe the clinical efficacy of Kangfang Fang combined with fluconazole in the treatment of respiratory tract fungal infection. Methods A total of 43 hospitalized patients with fungal respiratory tract infection were randomly divided into treatment group (n = 23) and control group (n = 20). The treatment group was given traditional Chinese medicine antifungal prescription, fluconazole orally, and the control group orally given fluconazole. 10d for a course of treatment, two courses of treatment of 1-2 courses. Compare the TCM syndrome scores before and after treatment, and observe the fungal culture results to calculate the fungal clearance rate. Results The fungal clearance rate was 60.87% in the treatment group and 40.00% in the control group, with significant difference between the two groups (P <0.05). The two groups of TCM syndromes, the total effective rate was 95.65% in the treatment group and 70.00% in the control group, the difference was statistically significant (P <0.05). Conclusion Mildew prescription combined with fluconazole in the treatment of respiratory tract fungal infection has a good clinical effect.