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目的:观察泮托拉唑对危重症患者预防应激性溃疡的效果。方法:对2008年10月-2011年6月收治的115例危重症患者随机分为研究组(58例)和对照组(57例),对2组患者均给予常规的抢救,另外对研究组患者及时给予泮托拉唑钠治疗,对照组患者给予西咪替丁治疗。观察2组患者肝肾功能、应激性溃疡出血的发生率及死亡率。结果:2组患者治疗前后肝、肾功能差异均无统计学意义(P>0.05)。研究组应激性溃疡的发生率明显低于对照组(P<0.01),死亡率亦明显低于对照组(P<0.05)。结论:泮托拉唑能有效预防危重症患者应激性溃疡的发生,并有助于降低死亡率。
Objective: To observe the effect of pantoprazole on the prevention of stress ulcer in critically ill patients. Methods: One hundred and fifteen critically ill patients admitted from October 2008 to June 2011 were randomly divided into the study group (58 cases) and the control group (57 cases), and the two groups were given routine rescue. In addition, Patients were treated with pantoprazole sodium in a timely manner and patients in the control group were given cimetidine. The incidence of liver and kidney function, stress ulcer bleeding and mortality in two groups were observed. Results: There was no significant difference in liver and kidney function between the two groups before and after treatment (P> 0.05). The incidence of stress ulcer in study group was significantly lower than that in control group (P <0.01), and the mortality rate was also significantly lower than that in control group (P <0.05). Conclusion: Pantoprazole can effectively prevent the occurrence of stress ulcer in critically ill patients and help to reduce mortality.