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为了探讨乙型和丙型肝炎病毒（ＨＢＶ和ＨＣＶ）重叠感染者病毒相互干扰现象，对４４例患者血清检测诊断为ＨＢＶ和ＨＣＶ感染的慢性肝病患者，用原位杂交法检测了肝组织中ＨＢＶＤＮＡ和ＨＣＶＲＮＡ。２８例患者肝组织ＨＢＶＤＮＡ和ＨＣＶＲＮＡ同时阳性，两者阳性信号分布类型比较无明显差异（Ｐ＞０．０５），血清ＨＢｅＡｇ阳性和阴性组中肝组织中的ＨＢＶＤＮＡ和ＨＣＶＲＮＡ检出率无明显差异（Ｐ＞０．０５）。８例血清ＨＢｓＡｇ阴性者，肝组织ＨＢＶＤＮＡ阳性５例，ＨＣＶＲＮＡ阳性３例。结果提示，ＨＢＶ和ＨＣＶ重叠感染肝组织损伤加重，可能诱导一种病毒呈现潜伏状态，但不是病毒清除。
To investigate the mutual interference of hepatitis B and C (HCV) and hepatitis C virus (HCV) in patients with chronic hepatitis B virus (HBV) infection and hepatitis C virus (HCV) infection in 44 patients, HBVDNA was detected by in situ hybridization And HCV RNA. HBVDNA and HCVRNA were positive in the liver tissue of 28 patients (P> 0.05), while there was no significant difference in the detection rate of HBVDNA and HCV RNA in the serum of HBeAg-positive and -negative groups P> 0.05). Among 8 cases of HBsAg-negative patients, 5 were HBVDNA positive and 3 were HCV RNA positive. The results suggest that hepatitis and HCV overlap infection liver injury increased, may induce a latent state of the virus, but not the virus clearance.