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1985年3月至1986年3月,我室采用外周血淋巴细胞培养—BrdU参入—吖啶橙荧光染色—紫外线光解—Giemsa染色制备迟复制X染色体技术,对10名正常妇女、12名先天性卵巢发育不全综合征患者进行了观察,以探讨正常个体迟复制X染色体的类型及迟复制率;X染色体结构异常的迟复制的规律;长臂等臂X染色体的复制行为等。材料正常妇女10人,年龄:新生儿～48岁。先天性卵巢发育不全综合征12人,年龄:新生儿～31岁。病例1～4,染色体核型:45,X。病例5,核型:45,X/46,XX。病例6～8,核型:45,X/46,Xi(Xq)。病例9,核型:46,Xi(Xq),inv(10)(q21q23)。
March 1985 to March 1986, our room using peripheral blood lymphocyte culture - BrdU incorporation - acridine orange fluorescence staining - UV photolysis - Giemsa staining late replication X chromosome technology, 10 normal women, 12 congenital Ovarian hypoplasia syndrome were observed in patients with normal individuals to explore the type and late replication of X chromosomes late replication rate; X chromosome structural abnormalities of late replication rules; arm arm X chromosome replication behavior. Material Normal women 10 people, age: newborns ~ 48 years old. 12 cases of congenital ovarian hypoplasia syndrome, age: newborns ~ 31 years old. Cases 1-4, chromosome karyotype: 45, X. Case 5, Karyotype: 45, X / 46, XX. Cases 6 to 8, Karyotype: 45, X / 46, Xi (Xq). Case 9, Karyotype: 46, Xi (Xq), inv (10) (q21q23).