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本文研究了106例造血系统肿瘤患者的外周血单个核细胞(PBMC)的NK细胞毒活性和96例该病患者的外周血NDV诱生的IFN水平,并对其中部分患者用部分纯化的HuIFNα(Ly)和HuIFNr粗制品做了NK细胞毒活性的体外调节。结果表明:与正常人相比,疗前急淋(ALL)患者的NK活性非常显著降低(P<0.001);疗前何杰金氏和非何杰金氏病(HL和NHL患着也明显降低(P<
In this paper, NK cytotoxic activity of peripheral blood mononuclear cells (PBMCs) in 106 patients with hematopoietic tumors and IFNs induced by peripheral NDV in 96 patients were studied. Some patients were treated with partially purified HuIFNα Ly) and HuIFNr crude were subjected to in vitro modulation of NK cytotoxic activity. The results showed that NK activity was significantly lower in patients with acute lymphoblastic leukemia (ALL) than in normal controls (P <0.001). Hodgkin’s disease and non-Hodgkin’s disease Reduce (P <