Changes of Expression of Stretch-activated Potassium Channel TREK-1 mRNA and Protein in Hypertrophic

来源 :华中科技大学学报(医学英德文版) | 被引量 : 0次 | 上传用户:liff09020625
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The expression of stretch-activated potassium channel TREK-1 mRNA and protein of hypertrophic myocardium was measured. Using a model of hypertrophy induced by coarctation of abdominal aorta in male Wistar rats, the expression of TREK-1 mRNA and protein was detected by using semi-quantitative RT-PCR and Western blot respectively. At 4th and 8th week after constriction of the abdominal aorta, rats developed significant left ventricular hypertrophy. As compared to sham-operated group, stretch-activated potassium channel TREK-1 mRNA was strongly expressed and protein was up-regulated in operation groups (P<0.05). It was concluded that the expression of TREK-1 was up-regulated in hypertrophic myocardium induced by chronic pressure overload in Wistar rats. The expression of stretch-activated potassium channel TREK-1 mRNA and protein of hypertrophic myocardium was measured. Using a model of hypertrophy induced by coarctation of abdominal aorta in male Wistar rats, the expression of TREK-1 mRNA and protein was detected by using semi At Quant and RT-PCR and Western blot respectively. At 4th and 8th week after constriction of the abdominal aorta, rats developed significant left ventricular hypertrophy. As compared to sham-operated group, stretch-activated potassium channel TREK-1 mRNA was strongly expressed and It was concluded that the expression of TREK-1 was up-regulated in hypertrophic myocardium induced by chronic pressure overload in Wistar rats.
其他文献
请下载后查看,本文暂不支持在线获取查看简介。 Please download to view, this article does not support online access to view profile.
期刊
整个11月,火箭队都处在连败 的阴霾和结束连败的短暂胜利之 中。直到12月初,随着麦蒂的回 归,事态才有所好转。在12月6日 和12月8日,姚明均以鲜血为代 价,先后帮助球队战胜凯
由国家行政学院书画研究院、公安部边防管理局文学艺术界联合会、黑龙江省书法家协会、黑龙江边防总队等单位共同举办的张成生、鲍守华“两学一做”书法展,11月5日在国家行政
游泳安全提醒*入水前要做好充分的准备活动*选择好辅助器材,如救生圈和潜水镜等*不要冒险跳水*饭后45~60分钟内不要游泳游泳用具*合身的游泳衣裤:游泳衣不能太大,太大的在游泳
本文通过从师源与学源两个角度分析现在产品设计专业手绘教学存在的问题,明晰产品设计专业手绘针对的人群,学生学习手绘课程的最终目的,最后给出一些具有一定意义的教学方法,
目的:探讨卵巢早衰(POF)、卵巢功能低下、染色体异常、反复胚胎种植失败患者在辅助生殖助孕过程中行供卵冻融胚胎移植(FET)的临床疗效。方法:在本院行供卵FET的91个周期为研
随着社会经济的发展,人们科学文化素养的提高,促进了我国就业形势的转变。市场经济环境下的日益激烈的社会竞争导致了人们存在不同程度的生存压力,这在中职教育阶段的学生上
习近平总书记一直将困难群众挂在口中,放在心上,一再强调精准扶贫、攻坚脱贫。在扶贫要求和号召之下,国家出台了一系列扶贫利好政策,在政策落实的过程中,乡镇干部发挥着关键
突然崛起如平地惊雷,由弱到强,蜕变之快迅雷不及掩耳,谓之黑马。比如说本 赛季的洛城新老大快艇队,千年鱼腩,一朝翻身,叫人惊叹不迭。看如今的快艇全无 往常寄湖人篱下的的凄
人工晶状体植入术已成为完整的白内障手术必不可少的一部分 ,用人工晶状体替代混浊的晶状体 ,能安全有效地恢复屈光间质的透明性 ,裸眼即可重新获得极为清晰的视觉。目前人工