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目的探讨槐杞黄颗粒对反复呼吸道感染的临床治疗效果及对血Thr17细胞的变化。方法选择某院自2010年5月～2011年12月在儿科病房治疗的100例反复呼吸道感染的患儿,按照患儿登记的先后顺序,将患儿随机分为试验组和对照组,每组50例。对照组患儿给予常规的抗感染及相应的对症治疗,试验组在常规治疗的基础上加用槐杞黄颗粒口服,7d为一个疗程,治疗3个月后观察两组呼吸道感染复发次数及血Th17细胞的变化。结果治疗后试验组的临床症状均有明显的改善,总有效率分别为86.00%(43/50)、75.00%(35/50);治疗3个月后,Th17水平有所下降,对照组治疗前后差异无统计学意义(P=1.748,P﹥0.05),试验组治疗前后比较差异有统计学意义(P=2.247,P﹤0.05)。结论槐杞黄颗粒用于反复呼吸道感染,是通过调节血Th17细胞,进而影响Th17介导的中性粒细胞炎症,以增强患儿机体的免疫力,获得明显的治疗及预防效果。
Objective To investigate the clinical effect of Huaiqi Huang granule on recurrent respiratory tract infection and the change of Thr17 cells in blood. Methods A total of 100 children with recurrent respiratory tract infection who were treated in a pediatric ward from May 2010 to December 2011 in a hospital were randomly divided into experimental group and control group according to the sequence of children’s registration. 50 cases. The control group of children given conventional anti-infection and the corresponding symptomatic treatment, the experimental group on the basis of conventional treatment with Huai Qi Huang granules oral administration, 7d for a course of treatment, after 3 months of treatment, the number of respiratory tract infections and blood Th17 cell changes. Results After treatment, the clinical symptoms of the experimental group were significantly improved, the total effective rate was 86.00% (43/50), 75.00% (35/50); after 3 months of treatment, Th17 levels decreased in the control group There was no significant difference between before and after treatment (P = 1.748, P> 0.05). There was significant difference in the experimental group before and after treatment (P = 2.247, P <0.05). Conclusion Huaiqi Huang granules can be used to recruit respiratory tract infection repeatedly. It regulates the Th17-mediated neutrophilic inflammation by regulating the blood Th17 cells so as to enhance the immunity of children and obtain the obvious curative and preventive effects.