烟雾吸入不仅能损害肺气体交换功能,还能损害肺内血管性物质的代谢。血管舒缓素是一种在肺内代谢的血管活性物质,具有增强毛细血管通透性及扩张血管作用。作为炎症因子,还能调节内皮细胞功能。肺循环内95％以上的血管舒缓素被肺内皮细胞内酶系统破坏,主要是通经氨基肽酶P和血管紧张素转换酶的水解作用。作者观察了肺烟雾损伤对肺内血管舒缓素代谢的影响。将吸入烟雾大鼠肺脏取下,制成肺脏灌注和机械通气实验装置。灌注液和 Smoke inhalation can not only impair the function of lung gas exchange, but also damage the metabolism of vascular substances in the lungs. Vasopressin is a vasoactive substance that is metabolized in the lungs and has the effect of enhancing capillary permeability and dilating blood vessels. As an inflammatory factor, it also regulates endothelial cell function. More than 95% of the blood vessels in the pulmonary circulation Strychnine is destroyed by the enzyme system in the lung endothelial cells, mainly through the hydrolysis of aminopeptidase P and angiotensin-converting enzyme. The authors looked at the effects of lung smoke damage on pravastatin metabolism in the lungs. The lungs of inhaled smoke rats were removed to make lung perfusion and mechanical ventilation experimental device. Perfusion fluid and