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目的 :探讨 SPECT心功能测定评价非霍奇金淋巴瘤 (NHL )化疗后阿霉素 (ADM)心肌毒性的可行性。方法 :选择无心脏病基础的 4 4例 NHL患者作研究对象 ,采用常规 CHOP方案进行治疗。定期用 SPECT检测患者的心功能。结果 :化疗前后射血分数 (EF)、高峰射血率 (PER)和高峰充盈率 (PER)值比较 ,差别有显著性 (P<0 .0 5 ) ;体内 ADM累积量愈大 ,EF、PER和 PER值下降愈大 ,并以 PFR变化最敏感。结论 :SPECT心功能测定是评价 NHL患者 ADM心肌毒性的敏感、适用的方法。
Objective : To investigate the feasibility of SPECT cardiac function assessment of myocardial toxicity of adriamycin (ADM) after non-Hodgkin’s lymphoma (NHL) chemotherapy. Methods: Forty-four NHL patients without heart disease were selected as subjects and treated with conventional CHOP regimen. Regular use of SPECT detects the patient’s heart function. Results: The ejection fraction (EF), peak ejection rate (PER) and peak filling rate (PER) values before and after chemotherapy were significantly different (P<0.05). The larger the cumulative ADM in vivo, EF, The greater the decrease in PER and PER values, the more sensitive to changes in PFR. Conclusion: SPECT cardiac function test is a sensitive and applicable method for evaluating myocardial toxicity of ADM in patients with NHL.