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为研究癞葡萄水提物对正常小鼠及四氧嘧啶型糖尿病小鼠血糖浓度的影响,将不同剂量(250mg/kg体重、500mg/kg体重和750mg/kg体重)的水提物灌胃给予禁食12h的正常小鼠和四氧嘧啶型糖尿病小鼠。试验结果表明,癞葡萄水提物对正常小鼠的血糖浓度没有影响,而对四氧嘧啶型糖尿病小鼠的血糖浓度有显著影响。其中500mg/kg剂量组糖尿病小鼠的血糖值在灌胃4h后较相应的初始血糖值下降45.28%,糖尿量提高38.39%;给予500mg/kg水提物治疗15d后,糖尿病小鼠血糖值较治疗前下降59.88%,同时对小鼠体重的恢复有一定的促进作用。结果表明癞葡萄水提物对四氧嘧啶型糖尿病小鼠具有良好的预防和治疗效果。
In order to study the effect of water extract of grape eucalyptus on blood glucose level in normal mice and alloxan-type diabetic mice, water extracts of different doses (250 mg/kg body weight, 500 mg/kg body weight, and 750 mg/kg body weight) were intragastrically administered. Fasted for 12 h in normal mice and alloxan-type diabetic mice. The test results showed that the water extract of alfalfa grape had no effect on blood glucose concentration in normal mice, but had a significant effect on blood glucose concentration in alloxan-type diabetic mice. The blood glucose level of the 500 mg/kg diabetic group was 45.28% lower than the corresponding initial blood glucose level and 38.39% of the glucosuria after gavage for 4 hours; the blood glucose level of the diabetic mice was 15 days after the 500 mg/kg water extract treatment. The decrease was 59.88% before treatment, and at the same time it had a certain role in promoting the recovery of body weight in mice. The results showed that the water extract of grape locust has a good preventive and therapeutic effect on alloxan-type diabetic mice.