设计合成了14 个2( E)(2甲氧基苯亚甲基) 环戊酮Mannich 碱类化合物,其中11 个为未见文献报道的新化合物.初步药理实验结果显示:6 个化合物在200 mg·kg- 1 剂量下对二甲苯致小鼠耳肿胀的抑制率为30 % ～53 % ;5 个化合物对小鼠移植性肿瘤S180 有明显的抑制作用 14 Mannich bases of 2  (E)  (2methoxybenzylidene) cyclopentanone were designed and synthesized, of which 11 were new compounds which were not reported in the literature.The results of preliminary pharmacological experiments showed that 6 Compounds at the dose of 200 mg · kg-1 induced a decrease of ear swelling in mice by 30% -53%. Five compounds significantly inhibited S180-induced transplantion in mice