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以阿霉素(多柔比星)、表阿霉素(表柔比星)和吡喃阿霉素(吡柔比星)为代表的蒽环类抗癌药作为最有效的化疗药之一,目前在临床上广泛应用于白血病、乳腺癌、肺癌、淋巴瘤等多种恶性肿瘤,具有抗瘤谱广、临床疗效高等显著特点,是多种化疗方案的核心药物。然而,剂量依赖性不可逆的心脏毒性严重限制了其使用。现就国内外近年对蒽环类药物心脏毒性的发病机制、监测等方面的进展予以综述。
Anthracycline anticancer drugs, such as doxorubicin (doxorubicin), epirubicin (epirubicin), and pirarubicin (pirarubicin), are among the most effective chemotherapeutic drugs Currently, it is widely used clinically in many kinds of malignant tumors such as leukemia, breast cancer, lung cancer and lymphoma. It has obvious anti-tumor spectrum and high clinical curative effect. It is the core drug of various chemotherapy regimens. However, dose-dependent irreversible cardiotoxicity severely limits its use. Now on the domestic and international anthracycline cardiotoxicity in recent years, the pathogenesis, monitoring and so on are reviewed.