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目的探讨经鼻空肠肠内营养支撑对重症急性胰腺炎肠源性感染患者的临床应用效果及价值。方法将我院2013年3月~2015年3月收治的重症急性胰腺炎肠源性感染患者110例作为实验研究对象,采用随机法分成观察组与对照组,各55例,对照组采用肠外营养治疗,观察组采用经鼻空肠肠内营养治疗,比较分析两组患者临床治疗效果、并发症出现几率及肠源性感染指标变化情况。结果观察组患者临床治疗总有效率为94.55%(52/55),对照组治疗总有效率是90.91%(50/55),两组相比无显著差异,P>0.05;两组患者都没有出血消化道穿孔、胰周脓肿等并发症,对照组患者有2例出现腹胀、5例出现腹泻,观察组腹胀、腹泻各出现1例,并发症发生几率无明显差异,P>0.05;观察组患者肠源性感染指标中的白细胞、C反应蛋白都显著低于对照组,P<0.05。结论经鼻空肠肠内营养支撑能显著降低重症急性胰腺炎肠源性感染发生几率,改善其生活质量,值得使用与推广。
Objective To investigate the clinical effect and value of nasal jejunum enteral nutrition support for patients with severe acute pancreatitis gut infection. Methods One hundred and ten patients with enteric infection of severe acute pancreatitis who were treated in our hospital from March 2013 to March 2015 were selected as experimental subjects and randomly divided into observation group and control group with 55 cases in each group. Nutritional therapy, the observation group was treated with enteral nutrition by nasal jejunum, the clinical efficacy of the two groups were compared and analyzed, the incidence of complications and the changes of gut-derived infection index were compared. Results The total effective rate of clinical observation was 94.55% (52/55) in observation group and 90.91% (50/55) in control group, there was no significant difference between the two groups (P> 0.05) Bloody digestive tract perforation, peripancreatic abscess and other complications, the control group of patients with bloating in 2 cases, 5 cases of diarrhea, abdominal distension in observation group, 1 case of diarrhea, the incidence of complications no significant difference, P> 0.05; observation group The levels of leukocyte and C-reactive protein in patients with intestinal infection were significantly lower than those in the control group (P <0.05). Conclusion Naso-jejunal enteral nutrition support can significantly reduce the incidence of severe acute pancreatitis in patients with intestinal infection, improve their quality of life, it is worth using and promotion.