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本文选择未接受任何治疗经病理确诊的子宫颈癌患者,子宫良性疾患者和健康妇女各6例。三组受试者外周血淋巴细胞的姊妹染色单体互换率(SCE)分别为0.189±0.027、0.133±0.020和0.102±0.014。经统计学处理,子宫颈癌组的 SCE 值与健康妇女组有十分显著的差异(P<0.001);而子宫良性疾患组的 SCE 值与健康妇女组也有较显著差异(P<0.05)。本文就病理组织类型不同的同种肿瘤患者 SCE 值的不同反映作了初步分析,并对这一细胞遗传学指标在宫颈癌及其癌前病变监护中的应用价值进行了讨论。
This selection of patients who have not received any treatment of pathologically confirmed cervical cancer, uterine benign disease and healthy women in 6 cases. The sister chromatid exchange rates (SCE) of peripheral blood lymphocytes in three groups of subjects were 0.189 ± 0.027, 0.133 ± 0.020 and 0.102 ± 0.014, respectively. There was a significant difference (P <0.001) between the SCE value of cervical cancer group and that of healthy women, while the SCE value of benign uterine disease group was also significantly different from that of healthy women (P <0.05). This article made a preliminary analysis of the different values of SCE in different types of patients with different pathological types of cancer, and discussed the value of this cytogenetic marker in the monitoring of cervical cancer and its precancerous lesions.