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目的探讨贝那普利联合美托洛尔治疗老年原发性高血压合并心力衰竭的疗效。方法 100例原发性高血压合并心力衰竭的老年患者,随机分为研究组和对照组,各50例。研究组接受贝那普利联合美托洛尔治疗,对照组服用贝那普利治疗。比较两组治疗疗效及治疗期间射血分数(EF)及N末端脑钠肽原(NT-pro BNP)。结果研究组老年原发性高血压治疗疗效有效率为88%,对照组为72%,比较差异具有统计学意义(P<0.05)。研究组治疗后EF值为(52.8±8.7)%、NT-pro BNP为(237±45),对照组分别为(43.8±9.2)%、(326±57);两组比较差异具有统计学意义(P<0.05)。结论贝那普利联合美托洛尔治疗老年原发性高血压合并心力衰竭疗效肯定,能够明显改善患者症状。
Objective To investigate the efficacy of benazepril combined with metoprolol in the treatment of elderly patients with essential hypertension complicated with heart failure. Methods 100 elderly patients with essential hypertension complicated with heart failure were randomly divided into study group and control group, with 50 cases in each group. The study group was treated with benazepril combined with metoprolol and the control group with benazepril. Efficacy of treatment and ejection fraction (EF) and N-terminal pro-brain natriuretic peptide (NT-pro BNP) were compared between the two groups. Results The effective rate of treatment of senile essential hypertension was 88% in the study group and 72% in the control group, with statistical significance (P <0.05). The EF of the study group was (52.8 ± 8.7)%, the NT-pro BNP was (237 ± 45) and the control group was (43.8 ± 9.2)% and (326 ± 57) respectively. The difference between the two groups was statistically significant (P <0.05). Conclusion The combination of benazepril and metoprolol in the treatment of elderly patients with essential hypertension complicated with heart failure has definite curative effect and can significantly improve the symptoms of patients.