狗灌胃(ig)β-羧乙基锗倍半氧化物(Ge-132)100、300、500mg/kg及静脉注射(iv)50mg/kg后。药物动力学分别为开放型一房室和二房室模型。ig(100mg/kg)血清中的半衰期约为5.7h,iv半衰期约为2.6h,ig的生物利用度为34.31％。Ge-132大鼠ig在肠、胃中的含量最高,其次是生殖器、肾、膀胱、肌肉、心、脑最少。狗ig(100mg/kg)后48h尿中的累积排泄量为给药量的29.9％,粪便中为61.1％,胆汁2.3％,总计93.3％。血浆蛋白结合率17—23％。 Dogs were intragastrically administered (ig) 100,300,500 mg / kg of β-carboxyethylgermanium sesquioxide (Ge-132) and 50 mg / kg iv (iv). Pharmacokinetics were open one-compartment and two-compartment models. ig (100mg / kg) serum half-life of about 5.7h, iv half-life of about 2.6h, ig bioavailability of 34.31%. Ge-132 rat ig in the intestine, stomach content highest, followed by genital, kidney, bladder, muscle, heart, brain at least. The cumulative excretion of urine 48 hours after dog ig (100 mg / kg) was 29.9% of dosing, 61.1% in feces, 2.3% of bile and 93.3% in total. Plasma protein binding rate of 17-23%.