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应用组织胺气道激发试验测定17例缓解期哮喘患者和10例健康人的气道反应性，同时检测气道激发前后血清中IL-8含量变化。结果表明：（1）哮喘患者血清中IL-8含量明显高于健康对照组；（2）哮喘患者呈气道高反应性，气道激发后血清中IL-8含量显著下降。提示IL-8在哮喘的气道反应性及其发病中起重要作用。
The airway responsiveness of 17 asthmatic patients with remission and 10 healthy controls were measured by histamine-induced airway provocation test. The levels of IL-8 in serum were measured before and after airway stimulation. The results showed that: (1) Serum IL-8 levels in asthmatic patients were significantly higher than those in healthy controls; (2) Airway hyperresponsiveness was observed in asthmatic patients, and serum IL-8 levels were significantly decreased after airway challenge. It is suggested that IL-8 plays an important role in the airway responsiveness and pathogenesis of asthma.