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目的观察EB病毒(EBV)潜伏膜蛋白1(LMP-1)在鼻咽癌(NPC)组织中的表达,探讨LMP-1在NPC诊断、治疗中的意义。方法采用MaxVision免疫组化的方法检测40例NPC组织及30例鼻咽炎组织中LMP-1的表达,分析LMP-1表达与NPC临床病理特征的关系。结果LMP-1在NPC组织的阳性表达率显著高于鼻咽炎组织(7 2.5 0%vs.1 6.6 7%)(P<0.0 5)。LMP-1阳性表达在NPC不同病理学分级及有无颈淋巴结转移方面均无统计学差异(P>0.05)。结论LMP-1在NPC组织中的表达显著高于鼻咽炎组织。应用EBV LMP-1作为NPC辅助诊断及靶向治疗的肿瘤相关分子标志具有一定可行性。
Objective To observe the expression of Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) in nasopharyngeal carcinoma (NPC) and to explore the significance of LMP-1 in the diagnosis and treatment of NPC. Methods MaxVision immunohistochemical method was used to detect the expression of LMP-1 in 40 cases of NPC and 30 cases of nasopharyngitis. The relationship between LMP-1 expression and clinicopathological features of NPC was analyzed. Results The positive expression rate of LMP-1 in NPC was significantly higher than that in nasopharyngitis (7 2.5 0% vs.1 6.6 7%) (P <0.05). There was no significant difference in the expression of LMP-1 in different pathological grades of NPC and with or without cervical lymph node metastasis (P> 0.05). Conclusion The expression of LMP-1 in NPC tissues was significantly higher than that in nasopharyngitis tissues. The application of EBV LMP-1 as NPC-assisted diagnosis and targeted therapy of tumor-associated molecular markers has some feasibility.