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[Objective] To systematically review the combination effects of entecavir and Compound Biejiaruangan Tablet on serum hepatic fibrosis markers of chronic hepatitis B.[Methods]Computer retrieval of CNKI,VIP,WANFANG DATA and CBM was carried out as well as Pub Med,Embase,Web of Science and the Cochrane Library.Retrieval time was from database foundation to January 2015.Literatures were screened according to the inclusion and exclusion criteria.After further extracting and analyzing the literatures,Meta analysis was carried out by Rev Man 5.3 software provided by Co-chrane collaboration network.[Results] Seven clinical randomized controlled trials were included.Among the 539 patients,272 cases were observation group and 267 cases were control group.The four indicators of serum hepatic fibrosis in treatment group reduced significantly compared with that in entecavir group(P<0.05),which were hyaluronic acid( HA),laminin( LN),procollagen III,collagen Ⅳ( IV-C).[Conclusions] Combination of entecavir and Compound Biejiaruangan Tablet significantly reduced the serum hepatic fibrosis markers of chronic hepatitis B.However,further verification test was still needed due to the poor research quality.
[Objective] To systematically review the combination effects of entecavir and Compound Biejiaruangan Tablet on serum hepatic fibrosis markers of chronic hepatitis B. [Methods] Computer retrieval of CNKI, VIP, WANFANG DATA and CBM was carried out as Pub Pub, Embase, Web of Science and the Cochrane Library. Retrieval time was from database foundation to January 2015. Literatures were screened according to inclusion and exclusion criteria. After further extracting and analyzing the literatures, Meta analysis was carried out by Rev Man 5.3 software provided by Co -chrane collaboration network. [Results] Seven clinical randomized controlled trials were included. Among the 539 patients, 272 cases were observation group and 267 cases were control group. the four indicators of serum hepatic fibrosis in treatment group reduced significantly compared with that in entecavir (P <0.05), which were hyaluronic acid (HA), laminin (LN), procollagen III, collagen Ⅳ (IV-C). [Conclusions] Combination of ent ecavir and Compound Biejiaruangan Tablet significantly reduced the serum hepatic fibrosis markers of chronic hepatitis B.However, further verification test was still needed due to the poor research quality.