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青少年型甲状腺机能低下常伴发多毛症,但还未见伴发卷毛的病例的报道.本文报道1例15岁的日本姑娘,患有典型的青少年型甲状腺机能低下,伴有背部及上臂伸侧的多毛和过度角化,并在肩胛部位出现毛囊性黑色晕、毳毛呈环状卷曲,埋在半透明的薄的角质层下方.患者10岁以前发育正常,12岁时身长较同龄儿为矮,智力正常.体检发现除身高133.3cm、体重31.1kg外余均正常.血象检查示轻度贫血:RBC3.33×10~6,Hb11.3g,WBC4200,分类正常.尿、血沉、肝功、GOT、GPT、LAP、胆硷脂酶、醛缩酶、γ-GTP、LDH等均在正常范围.甲状腺及垂体内分泌试验均提示原发性甲状腺机能低下从皮肤活检中发现在显著的角化的角质层下有些毛干呈水平或垂直方向地卷入在真皮内,而未穿透表皮,真皮和毛囊无明显改变.
Juvenile hypothyroidism is often associated with hirsutism but no cases of curly hair have yet been reported.This article reports a 15-year-old Japanese girl suffering from a typical juvenile hypothyroidism with dorsal and upper extensor Lateral hirsutism and hyperkeratosis, and appear in the scapular hair follicles black halo, beard hair ring curled, buried in the translucent thin stratum corneum below the normal development of patients before the age of 10, 12-year-old compared to the same age as children of short stature , Normal intelligence.Physical examination found that in addition to height 133.3cm, weight 31.1kg outside the extraterrestrial were normal.Check blood test showed mild anemia: RBC3.33 × 10 ~ 6, Hb11.3g, WBC4200, classification is normal.Urinary, ESR, liver function, GOT, GPT, LAP, cholinesterase, aldolase, γ-GTP, LDH, etc. are in the normal range of thyroid and pituitary endocrine tests have prompted the primary hypothyroidism from the skin biopsy found in significant keratinization Some hair follicles under the stratum corneum horizontal or vertical direction into the dermis, without penetrating the epidermis, dermis and hair follicles no significant change.