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华南马尾杉[Phlegmariurus fordii(Baker)Ching]为石杉科(Huperziaceae)新品种植物。我们于1970年在对三千多种中草药普筛中发现,华南马尾杉水煎剂对胆碱酯酶具有保护作用。为此,对其生物碱成分进行了系统分离鉴定。从中分得几个生物碱成分,其中一个生物碱经光谱分析及X射线单晶衍射证明为新成分,我们将其命名为福定碱(fordine)。进一步药理实验证明,它是一种新结构类型的胆碱酯酶保护剂,对真性胆碱酯酶具有选择性抑制作用。本文对福定碱的结构测定作一概述。
The Phinemariurus fordii (Baker) Ching is a new species of Huperziaceae. In 1970, we found that more than 3,000 kinds of Chinese herbal medicines were used in the screening, and the decoction of southern China’s cedarwood had a protective effect on cholinesterase. For this purpose, the alkaloid components were systematically identified and identified. Several alkaloidal components were isolated from them. One of the alkaloids was proved to be a new component by spectroscopic analysis and X-ray single crystal diffraction. We named it as fordine. Further pharmacological experiments have shown that it is a new structural type of cholinesterase protectant that selectively inhibits true cholinesterase. This article gives an overview of the determination of the structure of fudoxine.