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随着雌激素受体(Estrogen Recept-or,ER)的发现,1971年Jensen首先报告测定乳腺肿瘤组织的ER可以预测对内分泌治疗的效果。近十多年来大量的临床研究都肯定了这个结果,乳腺癌激素受体的测定对选择治疗方法具有指导作用。一、雌激素受体的作用原理:雌激素属类固醇激素,具有甾核的结构,雌激素受体具有高度的特异性的亲和力,只能和雌激素特异的结合。受体作用机制是按照“二步作用”原理进行的,首先雌激素通过扩散经过细胞膜进入细胞质和雌激素受体相结合,形成雌激素——雌激素受体复
With the discovery of the Estrogen Receptor (ER), Jensen first reported in 1971 that the determination of ER in breast tumor tissue can predict the effects of endocrine therapy. A large number of clinical studies have confirmed this result in the past decade. The determination of hormone receptors in breast cancer has a guiding role in the selection of treatment methods. First, the principle of estrogen receptors: estrogen is a steroid hormone, has the structure of the nucleus of the nucleus, the estrogen receptor has a high degree of specific affinity, and only estrogen-specific binding. The receptor mechanism of action is based on the “two-step action” principle. First, estrogen diffuses through the cell membrane and enters the cytoplasm and estrogen receptors to form an estrogen-estrogen receptor complex.