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妊娠巨幼细胞贫血(简称妊娠巨贫)是由于妊娠时缺乏叶酸和/或维生素B_(12)所引起的一组营养性贫血,多发生在妊娠中末期或产后期,故亦称为产前(后)营养缺乏性贫血。现将该病近年来研究的现状综述如下。发病情况 Giles报告335例妊娠巨贫,平均年龄28.7(15～45)岁。另一组18例平均年龄26.2(19～38)岁。关于本病的发病情况,各家报告不同,一组报告孕妇中巨贫占2.8％,另一组154例孕妇中巨贫15例(9.7％)。产前不给铁剂治疗时其发病率可高达16.6％。Lowenstein报告62例孕妇,产前未给任何治疗,其中16例(26％)发生巨贫。Hansen发现孕妇骨髓中有血细胞形态改变者占1/3,大部分发生在妊娠末3个月,9个月是发病高峰,于分娩后7周骨髓中仍可检出巨幼红细胞。
Pregnancy megaloblastic anemia (referred to as giant pregnancy) is due to lack of folic acid and / or vitamin B_ (12) in pregnancy caused by a group of nutritional anemia, occurred in the late pregnancy or postnatal period, it is also known as prenatal (After) nutritional deficiency anemia. Now the disease in recent years the status of research are summarized below. The incidence of Giles report 335 cases of pregnancy-poor, with an average age of 28.7 (15 to 45) years old. The other group of 18 patients with an average age of 26.2 (19 to 38) years old. About the incidence of this disease, different reports, a group of pregnant women accounted for 2.8% of the poor, another 154 cases of pregnant women in 15 cases (9.7%). The incidence of iron can be as high as 16.6% during prenatal treatment. Lowenstein reported 62 pregnant women with no prenatal treatment and 16 of them (26%) who were poor. Hansen found that the blood cells in pregnant women with blood cell morphology changes accounted for 1/3, most occurred in the third trimester of pregnancy, 9 months is the peak incidence of bone marrow in the 7th week after delivery can still be detected in megaloblastic.