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目的：研究长期住ＩＣＵ患者获得性深部真菌感染的发生特点及防治对策。方法：回顾性分析１９９５年１月～１９９７年１２月我院ＳＩＣＵ连续长期住院患者６５例，定期采取呼吸道（痰液）、血液、尿液、中心静脉插管、各种引流及伤口深部拭子标本，行微生物培养及药敏试验。结果：６５例患者中微生物培养阳性者４９例（７５．４％）；其中单纯真菌感染者２例（３．１％）；真菌合并细菌感染者１８例（２７．７％）。真菌感染的总发生率为４０．８％（２０／４９）。共获得真菌４１株，念珠菌属仍是主要感染病原体，占全部４１株的５６．１％以上，但白色念珠菌感染比例显著下降。结论：ＩＣＵ中真菌感染最常见于呼吸道和泌尿道，感染发生率与患者年龄、留治时间及机械通气时间有关。应用广谱强力抗生素可以造成菌群失调而引发深部真菌感染。非白色念珠菌类念珠菌正成为深部真菌感染的主要病原菌
Objective: To study the characteristics and prevention and treatment of acquired deep fungal infection in long-term ICU patients. Methods: A retrospective analysis of 65 consecutive hospitalized patients with SICU in our hospital from January 1995 to December 1997 was retrospectively analyzed. The respiratory tract (sputum), blood, urine, central venous cannulation, various deep drainage swabs Specimens, culture and microbiological susceptibility testing. Results: Of the 65 patients, 49 (75.4%) were positive for microbial culture, among which 2 were fungal infections (3.1%) and 18 were fungal infections (27.7%). The total incidence of fungal infections was 40.8% (20/49). A total of 41 fungi were obtained. Candida were still the major infectious pathogens, accounting for 56.1% of all 41 strains, but the proportion of Candida albicans significantly decreased. Conclusion: The most common fungal infections in the ICU are in the respiratory tract and urinary tract. The incidence of infection is related to the age of patients, the time of treatment and the duration of mechanical ventilation. Application of broad-spectrum powerful antibiotics can cause flora and lead to deep fungal infections. Candida albicans is becoming the major pathogen of deep fungal infections