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目的研究和分析颅内动脉瘤性蛛网膜下腔出血患者早期血清sICAM-1含量与病情及预后的关系。方法用ELISA法测定56例颅内动脉瘤性蛛网膜下腔出血患者发病72h内血清sICAM-1含量,结合患者入院Hunt-Hess分级、Fisher分级及出院后(6-12月)GOS评分等资料行统计分析。结果实验组sICAM-1含量高于对照组(P<0.05),且sICAM-1含量与患者入院时临床症状、SAH程度及预后密切相关,患者病情及SAH程度越重,sICAM-1浓度越高,GOS评分越低。结论患者早期血清sICAM-1含量可以反映患者临床症状与SAH程度的严重程度,还可作为早期预后评估的重要指标。
Objective To study and analyze the relationship between serum sICAM-1 and prognosis in patients with intracranial aneurysmal subarachnoid hemorrhage. Methods Serum levels of sICAM-1 in 56 patients with intracranial aneurysmal subarachnoid hemorrhage were detected by ELISA. The serum levels of sICAM-1 were determined by Hunt-Hess classification, Fisher classification and post-discharge GOS score (6-12 months) Line statistical analysis. Results The content of sICAM-1 in the experimental group was significantly higher than that in the control group (P <0.05). The content of sICAM-1 in the experimental group was closely related to the clinical symptoms, the degree of SAH and the prognosis of patients on admission. The higher the severity of the disease and SAH, the higher the concentration of sICAM-1 , The lower the GOS score. Conclusion The serum level of sICAM-1 in early stage of patients can reflect the severity of clinical symptoms and SAH, and can also be used as an important index in early prognosis evaluation.