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[目的]探讨中西医结合治疗糖尿病胃轻瘫患者疗效观察及对患者血清胃动素、瘦素、生长抑素的影响。[方法]选自我院于2014年10月~2016年10月收治的糖尿病胃轻瘫患者84例,按照随机表法分为观察组42例与对照组42例。观察组采用中西医结合治疗,对照组仅采用西医治疗。2组疗程均为4周。比较2组治疗疗效,治疗前后主要症状评分、胃动素、瘦素和生长抑素、胃排空时间和胃排空率,及随访6个月复发情况。[结果]观察组总有效率(92.86%)高于对照组(66.67%)(P<0.05);观察组治疗后上腹疼痛、脘腹胀满、恶心呕吐、早饱评分低于对照组(t=17.923、15.325、13.426、19.741,P<0.05);观察组治疗后血清胃动素、瘦素和生长抑素水平低于对照组(t=9.798、8.105、9.404,P<0.05);观察组治疗后胃排空时间低于对照组而胃排空率高于对照组(t=9.121、6.999,P<0.05);观察组复发率(4.76%)低于对照组(26.19%)(P<0.05)。[结论]中西医结合治疗糖尿病胃轻瘫患者疗效显著,可通过降低血清胃动素、瘦素、生长抑素,改善胃肠运动,且复发率低,具有重要研究意义。
[Objective] To investigate the curative effect of combination of traditional Chinese and western medicine on diabetic gastroparesis and its effect on serum motilin, leptin and somatostatin. [Method] Eighty-four patients with diabetic gastroparesis selected from our hospital from October 2014 to October 2016 were randomly divided into observation group (42 cases) and control group (42 cases). Observation group using Integrative Medicine treatment, the control group only treated with Western medicine. The two courses of treatment were 4 weeks. The curative effect, the main symptom scores before and after treatment, motilin, leptin and somatostatin, gastric emptying time and gastric emptying rate were compared between two groups. The recurrence was followed up for 6 months. [Results] The total effective rate (92.86%) in the observation group was significantly higher than that in the control group (66.67%) (P <0.05). The observation group had lower abdominal pain, abdominal distention, nausea and vomiting, = 17.923,15.325,13.426,19.741, P <0.05). The levels of motilin, leptin and somatostatin in the observation group were lower than those in the control group (t = 9.798, 8.105,9.404, P <0.05) The gastric emptying time after treatment was lower than that of the control group and the gastric emptying rate was higher than that of the control group (t = 9.121,6.999, P <0.05). The recurrence rate of the observation group (4.76%) was lower than that of the control group (26.19% 0.05). [Conclusion] Integrative treatment of diabetic gastroparesis patients with significant effect, by reducing serum motilin, leptin, somatostatin, improve gastrointestinal motility, and the recurrence rate is of great research significance.