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幼淋巴细胞白血病(Prolymphocytic Leukemia简称PL)较为少见,是一种具有独特临床及实验室特点的白血病。1974年Galton等首先报告一组PL,临床以病程短暂、巨脾、浅表淋巴结肿大不显著、白细胞总数显著增高,以及对一般治疗反应不佳为特征。以往文献将PL归类于急淋白血病(ALL)或慢淋白血病(CLL);目前多认为PL系CLL的一种变异型。此病临床医师较为生疏,国内病例报道亦甚少。现将近年来国外研究情况综述如下。临床表现综合Galton等作者报告26例PL的临床表现,此病好发于老年人,年龄46~77岁,平均65岁,其中60岁以上23例。男性17例,女性9例。起病时多数有全身症状,26
Prolymphocytic leukemia (PL) is rare, is a unique clinical and laboratory characteristics of leukemia. In 1974, Galton et al. First reported a group of PLs characterized by transient course of disease, splenomegaly and superficial lymph node enlargement, markedly increased total leukocyte count, and poor response to general treatment. PL in the past literature classified as acute leukemia (ALL) or chronic leukemia (CLL); currently considered a variant of CLL PL line. Clinicians more unfamiliar with the disease, domestic case reports are few. In recent years, the research situation of foreign countries is summarized as follows. Clinical manifestations Galton and other authors report the clinical manifestations of 26 cases of PL, the disease occurs in the elderly, aged 46 to 77 years, mean 65 years, of which 23 were over 60 years of age. 17 males and 9 females. Most have systemic symptoms at onset, 26