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冠状动脉粥样硬化性心脏病(CAD)同血压升高程度、总胆固醇(CT)、低密度脂蛋白与极低密度脂蛋白胆固醇(LDL-C 与VLDL-C)、甘油三酯(TG)或 VLDL-TG 以及载脂蛋白(Apo)B 水平正相关,同高密度脂蛋白胆固醇(HDL-C)、ApoA_1、HDL_2呈负相关。临床冠心病脂质研究一级预防试验证实血浆 CT 降低1％,CAD 发生率降低2％。随机对照研究证实,尽管降压治疗使脑血管病、肾功能衰竭、高血压性心肌病明显减少,但对 CAD 影响很小。对此的解释不清
Coronary atherosclerotic heart disease (CAD) was associated with elevated blood pressure, total cholesterol (CT), low density lipoproteins and very low density lipoprotein cholesterol (LDL-C and VLDL-C), triglyceride Or VLDL-TG and apolipoprotein (Apo) B levels, but negatively correlated with HDL-C, ApoA_1 and HDL_2. Primary prevention trials in clinical coronary heart disease lipid studies have shown a 1% reduction in plasma CT and a 2% reduction in the incidence of CAD. Randomized controlled studies confirm that, although antihypertensive treatment of cerebrovascular disease, renal failure, hypertensive cardiomyopathy was significantly reduced, but little effect on CAD. The explanation is unclear