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目的:探讨新生儿窒息对新生儿高胆红素血症(下称高胆)的影响。方法:对418例窒息新生儿高胆的发生率进行回顾性临床分析。分轻度窒息组和重度窒息组,同期住院无窒息新生儿为对照组。对有皮肤黄疸的新生儿应用经皮胆红素测定仪动态观察,结果接近高胆诊断标准时,测血清胆红素浓度及肝功能。结果:轻度窒息组(279例)、重度窒息组(139例)、无窒息组(4 827例)高胆发生率分别为17.20%、10.07%、59.29%,三组间比较,差异有统计学意义(χ2=315.792,P<0.01),轻度窒息组与重度窒息组高胆发生率低于无窒息组;轻度窒息组与无窒息组相比,差异有统计学意义(χ2=188.893,P<0.01),轻度窒息组高胆发生率低于无窒息组;重度窒息组与无窒息组比较,差异有统计学意义(χ2=132.277,P<0.01),重度窒息组高胆发生率低于无窒息组;轻度窒息组与重度窒息组比较,差异无统计学意义(χ2=3.193,P>0.05)。结论:轻度窒息、重度窒息新生儿高胆发生率均低于无窒息新生儿。
Objective: To investigate the impact of neonatal asphyxia on neonatal hyperbilirubinemia (hereinafter referred to as “hypercholesterolemia”). Methods: A retrospective clinical analysis of the incidence of hyperbilirubinemia in 418 neonates with asphyxia. Sub-mild asphyxia group and severe asphyxia group, the same period asphyxiated neonatal as control group. Percutaneous bilirubin assay was used to observe the newborns with skin jaundice. The results were close to the diagnostic criteria of high bile, serum bilirubin concentration and liver function were measured. Results: The incidences of hypercholesterolemia in mild asphyxia group (279 cases), severe asphyxia group (139 cases) and no asphyxia group (4827 cases) were 17.20%, 10.07% and 59.29%, respectively. There were statistically significant differences among the three groups (Χ2 = 315.792, P <0.01). The incidence of hypercholesteremia in mild asphyxia group and severe asphyxia group was lower than that in non-asphyxia group (χ2 = 315.792, P <0.01). There was significant difference between mild asphyxia group and non-asphyxia group , P <0.01). The incidence of hypercholesteremia in mild asphyxia group was lower than that in non-asphyxia group. There was significant difference between severe asphyxia group and non-asphyxia group (χ2 = 132.277, P <0.01) There was no significant difference between mild asphyxia group and severe asphyxia group (χ2 = 3.193, P> 0.05). Conclusions: The incidence of hypercholesteremia in neonates with mild asphyxia and severe asphyxia are lower than those without asphyxia.