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随着表面增强拉曼光谱(SERS)技术的发展,SERS与标记免疫技术的结合已成为一种新的医学研究技术。该文从SERS标记免疫检测技术的原理、研究进展、存在问题等方面叙述了SERS标记免疫检测及其最新发展。归纳了目前提高SERS标记免疫检测灵敏度的研究技术及消除SERS免疫标记研究中非特异性吸附的方法。对SERS标记免疫技术未来的研究方向与发展前景进行了展望。
With the development of surface enhanced Raman spectroscopy (SERS), the combination of SERS and tagged immunosensor has become a new medical research technique. This paper describes the SERS marker immunoassay and its latest development from the aspects of the principle, research progress and existing problems of SERS marker immunoassay. The current research techniques to improve the sensitivity of SERS labeling immunoassay and the method to eliminate nonspecific adsorption in SERS immunoassay were summarized. The future research direction and development prospect of SERS labeling immunization technology are prospected.