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目的探讨冠心病合并2型糖尿病(T2DM)患者冠状动脉病变特点及相关危险因素,以及T2DM对冠状动脉病变的影响。方法2003年12月至2008年2月行冠状动脉造影确诊为冠心病的患者324例,按有无T2DM分为T2DM组82例,非DM组242例,比较2组之间的相关临床因素及冠状动脉造影情况、治疗情况。结果(1)T2DM组与非DM组比较,胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、体重指数(BMl)差异有统计学意义(P<0.05),T2DM组除HDL外其余指标均高于非DM组。T2DM组高血压、心肌梗死发生率高于非DM组(P<0.05)。(2)T2DM组病变血管支/例、多支病变、弥漫病变、血管中重度狭窄病变发生率均高于非DM组(P<0.05)。结论T2DM发生冠心病常与高血压、脂代谢紊乱和/或肥胖等因素同时存在,其冠状动脉病变程度加重,多支病变、弥散病变、心肌梗死等危险心脏事件发生率高。
Objective To investigate the characteristics and related risk factors of coronary artery disease in patients with coronary heart disease complicated with type 2 diabetes mellitus (T2DM) and the effect of T2DM on coronary artery disease. Methods From December 2003 to February 2008, 324 patients with coronary artery disease confirmed by coronary angiography were divided into T2DM group (n = 82) and non-DM group (242 patients) according to the presence or absence of T2DM and the related clinical factors Coronary angiography, treatment. Results (1) The difference of TC, TG, HDL, LDL and BMl between T2DM group and non-DM group was statistically significant (P <0.05). The other indexes in T2DM group except HDL were higher than those in non-DM group. The incidence of hypertension and myocardial infarction in T2DM group was higher than that in non-DM group (P <0.05). (2) The incidence of vascular lesion, multi-vessel lesion, diffuse lesion and severe vascular stenosis in T2DM group were higher than those in non-DM group (P <0.05). Conclusions The occurrence of coronary heart disease in T2DM is often accompanied by the presence of hypertension, dyslipidemia and / or obesity. The incidence of coronary artery disease is increased, and the incidence of multi-vessel disease, diffuse disease, myocardial infarction and other dangerous cardiac events is high.