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目的观察缺氧缺血性脑病(HIE)患儿接受神经生长因子(NGF)与纳洛酮联合治疗方案后血清S100B蛋白以及神经元特异性烯醇化酶(NSE)的变化,并分析其临床意义。方法选择2012年2月-2013年9月本院收治的60例HIE患儿为研究对象,随机分为对照组与实验组各30例,对照组接受常规治疗,实验组则采取NGF与纳洛酮联合治疗方案,2组疗程均为7 d。分别在治疗前后检测2组血清NSE水平以及S100B指数,评估2组NBNA评分。结果与对照组相比,实验组患儿治疗后血清S100B以及NSE水平均有大幅度的降低,NBNA评分更高,组间差异具有统计学意义(P<0.05)。结论对于缺氧缺血性脑病患儿来说,神经生长因子与纳洛酮联合治疗可有效控制血清S100B蛋白以及NSE指数水平,降低脑损伤,具有积极的临床意义,应予以推广使用。
Objective To investigate the changes of serum S100B protein and neuron specific enolase (NSE) in children with hypoxic-ischemic encephalopathy (HIE) receiving the combination of NGF and naloxone and to analyze their clinical significance . Methods Sixty children with HIE treated in our hospital from February 2012 to September 2013 were randomly divided into control group and experimental group, with 30 cases in each group. The control group received routine treatment. In the experimental group, NGF and Nalo Ketone combination regimen, two courses of treatment were 7 d. Before and after treatment, serum NSE level and S100B index were measured in two groups, and NBNA score was evaluated in two groups. Results Compared with the control group, the levels of serum S100B and NSE in the experimental group were significantly decreased, NBNA score was higher, the difference between the two groups was statistically significant (P <0.05). Conclusion For children with hypoxic-ischemic encephalopathy, the combination of NGF and nerve growth factor can effectively control the level of S100B protein and NSE index and reduce brain injury, which has a positive clinical significance and should be widely used.