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子宫内膜异位症(EMs)是育龄妇女常见病和多发病,发病率呈上升趋势,其病灶有着类似恶性肿瘤种植生长和远处转移的生物学特点,药物治疗及手术治疗方案存在着不良反应大及复发率高等缺陷。近年研究表明,血管新生在EMs的种植、生长与播散中起到重要作用。现从动物模型子宫内膜异位样病灶和人体EMs病灶的血管新生角度阐述血管新生在EMs发病中扮演的重要角色,并总结体外、在体的血管抑制治疗的方法与进展,同时展望将来对EMs患者的治疗。为阐述EMs病灶的血管新生分子机制和今后EMs的治疗提供新思路。
Endometriosis (EMs) is a common and frequently-occurring disease in women of childbearing age, the incidence is on the rise, the lesions have the biological characteristics of similar to the growth and distant metastasis of malignant tumors, drug treatment and surgical treatment program there is a defect Reactions and high recurrence rate defects. In recent years, studies have shown that angiogenesis play an important role in the cultivation, growth and dissemination of EMs. In this paper, we describe the important role of angiogenesis in the pathogenesis of EMs from the perspective of angiogenesis in animal models of endometriosis-like lesions and human EMs lesions, and summarize the methods and progress of in vitro and in vivo vascular suppression therapy, and look forward to the future Treatment of EMs patients. It provides new ideas for elucidating the molecular mechanism of angiogenesis in EMs and the treatment of EMs in the future.