目的:探讨阴茎癌肉瘤的组织学特点、临床表现、鉴别诊断、治疗及预后。方法:回顾性分析1例阴茎癌肉瘤患者的临床、病理和随访资料,并复习癌肉瘤及肉瘤样癌相关文献,对二者一并进行讨论。结果:术后病理检查见上皮源性及间叶源性两种恶性成分,癌组织CK5/6(+),P63(+),CK(+),CK8/18(+),但Vimentin(-),肉瘤组织Vimentin(+),Ki-67约40%,诊断为阴茎癌肉瘤,术后未行进一步治疗。结论:阴茎癌肉瘤是具有高度侵袭性、高度致死性恶性肿瘤,往往首诊时已表现为高级别与高分期的特征,预后不良。确诊依赖病理学及免疫组化检查,手术为首选治疗方法。 Objective: To investigate the histological features, clinical manifestations, differential diagnosis, treatment and prognosis of penile carcinosarcoma. Methods: The clinical, pathological and follow-up data of 1 patient with penile carcinosarcoma were retrospectively reviewed. The related literature of carcinosarcoma and sarcomatoid carcinoma was reviewed, and the two were also discussed. Results: Two malignant components, epithelial and mesenchymal, were found in pathological examination. The expressions of CK5 / 6 (+), P63 (+), CK (+) and CK8 / 18 (+ ), Sarcoma tissue Vimentin (+), Ki-67 about 40%, diagnosed with penile carcinosarcoma, no further treatment after surgery. Conclusions: Penile carcinosarcoma is a highly aggressive and highly lethal malignant tumor. It is often characterized by high grade and high staging at the time of first diagnosis. The prognosis is poor. Diagnosis depends on pathology and immunohistochemistry, surgery is the preferred method of treatment.