,Structure basis for the unique specificity of medaka enteropeptidase light chain

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Dear Editor,Enteropeptidase (enterokinase,EC 3.4.21.9) is a serine protease,which shows a specific cleavage of its substrates at the C-terminal of the recognition site (Asp)4Lys (Zheng et al.,2009).Because of the unique specificity,enteropeptidase could be used as a tool for the production of recombinant fusion proteins.Especially the recombinant enteropeptidase light chain (EPL),which contains a catalytic domain,is of large interest to be applied in biopharmaceutical industry (Lu et al.,1997).
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