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目的:探讨肝硬化与胆囊结石发生的相关性及在肝硬化状态下血浆白蛋白水平与胆囊结石发生的机理。方法:用B型超声检查,电子扫描观察胆囊结石的细微结构,采用双脲法和溴甲酚绿方法定量测定血浆白蛋白的含量,对298例肝硬化合并胆囊结石病人资料进行临床分析。结果:肝硬化代偿期胆囊结石发生率为15.6%,肝硬化失代偿期胆囊结石发生率为29.4%,肝硬化患者胆囊结石发生率为25.8%。不同分级之间有统计学差异(P<0.05)。结论:肝硬化病人胆囊结石发生率升高,肝硬化患者胆囊结石发生与肝功能受损,程度有关。
Objective: To investigate the correlation between cirrhosis and gallstone and the mechanism of serum albumin and gallstone in cirrhosis. Methods: The ultrastructure of gallbladder stones was observed by scanning electron microscopy with B type ultrasound. The contents of plasma albumin were measured by the method of diurea and bromocresol green. The clinical data of 298 patients with cirrhosis and gallstone were analyzed. Results: The incidence of decompensated gallstone in cirrhosis was 15.6%, the incidence of gallstone in decompensated cirrhosis was 29.4%, and the incidence of gallstones in cirrhosis was 25.8%. There was a statistically significant difference between different grades (P <0.05). Conclusion: The incidence of gallstone in cirrhotic patients is increased, and the incidence of gallstone in patients with cirrhosis is related to the degree of liver dysfunction.