左旋精氨酸(L-arginine,L-arg)作为一氧化氮(NO)的前质,在血管舒缩调节中有重要的作用。我们曾证实自发高血压大鼠(SHR)肠系膜动脉内皮依赖性舒张减弱并与EDRF有关.为进一步探讨此减弱的机制,本文应用微量生物测定法观察成年卒中SHR(SHRsp)和WKY大鼠的肠系膜动脉在PHE预收缩基础上对L-arg舒张反应,与左旋硝基精氨酸(NG-nitro-L-arginine,L-NNA)对此舒张的影响. L-arginine (L-arginine), as a precursor of nitric oxide (NO), plays an important role in the regulation of vasomotor. We have demonstrated that endothelium-dependent relaxation of the mesenteric artery in spontaneously hypertensive rats (SHRs) is attenuated and is associated with EDRF.To further investigate the mechanism of this decrease, micro-bioassay was used to observe the mesentery of adult stroke SHR (SHR) and WKY rats The effect of L-arg relaxation on the relaxation of arteries on the basis of PHE precontraction and L-NNA.