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目的探讨血清脂联素、瘦素水平与乳腺癌的相关性。方法通过流行病学调查收集新发乳腺癌病例123例,剔除拒绝采集血液标本的病例后得到乳腺癌患者43例。以该43例乳腺癌患者为病例组,以同社区、同年龄(±3岁)为配对标准,选择经临床检查或病理诊断排除乳腺癌的女性为对照组,按照1∶1进行配对,最终入组病例及对照共43对。酶联免疫吸附法(ELISA)测定血清脂联素、瘦素水平,进行配对t检验、χ2检验、条件Logistic回归分析等统计学处理。结果病例组血清脂联素水平低于对照组,瘦素水平高于对照组,脂联素/瘦素比值(A/L)低于对照组。Logistic回归分析结果显示,A/L与乳腺癌密切相关(OR=6.33,95%CI:1.87～21.40,P<0.01)。结论人群中乳腺癌患者较非乳腺癌患者有较低的血清脂联素水平,较高的血清瘦素水平。A/L与乳腺癌的发病具有明显相关性,此相关性明显优于单独脂联素或瘦素与乳腺癌发病的相关性。
Objective To investigate the correlation between serum adiponectin, leptin and breast cancer. Methods 123 cases of newly diagnosed breast cancer were collected through epidemiological investigation and 43 cases of breast cancer were obtained after removing the cases which refused to collect blood samples. The 43 cases of breast cancer patients as the case group, with the community, the same age (± 3 years) as the pairing criteria, select clinical examination or pathological diagnosis of breast cancer patients excluded as the control group, according to 1: 1 pairs, the final A total of 43 cases and control group. Serum adiponectin and leptin levels were measured by enzyme-linked immunosorbent assay (ELISA), paired t test, χ2 test and conditional logistic regression analysis were performed. Results Serum levels of adiponectin in the patients were lower than those in the control group, leptin level was higher than that in the control group, and adiponectin / leptin ratio (A / L) was lower than that in the control group. Logistic regression analysis showed that A / L was closely related to breast cancer (OR = 6.33, 95% CI: 1.87-21.40, P <0.01). Conclusion The population of breast cancer patients have lower serum adiponectin level and higher serum leptin level than non-breast cancer patients. A / L and breast cancer incidence has a significant correlation, this correlation was significantly better than adiponectin or leptin and breast cancer incidence.